The fights were announced by the UFC on Tuesday.
Sanchez will make his return to action after earning a disqualification win over Michel Pereira in his most recent fight following an illegal knee strike that ended the contest.
New Zealand featherweight Shane Young will also appear at UFC 253 when he faces the always exciting Nate Landwehr, who is coming of his first win in the promotion following a bloody war with Darren Elkins back in May.
Da Silva is coming off his first win in the UFC after earning a unanimous decision against Rodrigo Vargas last August.
The upcoming UFC 253 card will be headlined by a middleweight title fight where reigning champion Israel Adesanya takes on Brazilian powerhouse Paulo Costa in a highly anticipated and volatile showdown on Sept. 26. While the promotion hasn’t confirmed the location for the event, it’s likely UFC 253 will take place on Yas Island in Abu Dhabi.