The news was first reported by The Daily Telegraph and was later announced by the UFC.
This new main event replaces the original headliner between former UFC middleweight champion Luke Rockhold and top middleweight Ronaldo Souza. MMA Fighting reported on Monday that Rockhold had suffered a knee injury and was forced to withdraw from his rematch with 'Jacare', leaving the Australia card without a headliner.
Now fighting five rounds and not three, Australia's Whittaker looks to keep building on his impressive five-fight winning streak. In his latest streak, the 25-year-old fighter has put together win over notable opponents such as Rafael Natal, Uriah Hall and Brad Tavares. Whittaker is 4-0 since moving up to the 185-pound division in 2014 and now stands at No. 7 in the UFC's middleweight rankings.
His opponent, Brunson is also riding a five-fight winning streak, and sits just one stop behind Whittaker in rankings at No. 8. The 32-year-old fighter last fought at UFC Fight Night 94 in September, defeating Uriah Hall via first-round technical knockout.
UFC Fight Night 101 is set to take place on Nov. 27 at Rod Laver Arena in Melbourne, Australia.