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The 14-year veteran announced his retirement from the sport this week. Sportsnet.ca first reported the news on Thursday.
"I've had a great MMA career," MacDonald told MMAFighting.com. "I have traveled, met great people and have done things I would have never dreamed of through MMA. It's been an honor to be with the UFC over the years, but it's now time to move on. I'm getting older, my four kids are growing up fast. I'm going to focus on my family and my CrossFit gym."
"The Athlete" was called the "TUF Killer" when he started his UFC career in 2006 because he impressively defeated The Ultimate Fighter cast members Ed Herman and Chris Leben in his first two UFC fights.
The 37-year-old's last win inside the Octagon came against Ryan Jensen at the record-breaking UFC 129 event in April 2011.