
Griffin, who was scheduled to face Antonio Rogerio Nogueira, reportedly injured his shoulder, forcing him to pull out of the event, which is to be held on May 29 in Las Vegas.
Griffin (17-6) rebounded from back-to-back losses in his last match at UFC 106, earning a split decision against Tito Ortiz.
The loss of Griffin is a big loss to the card, as his fight with Nogueira -- the younger brother of former UFC interim heavyweight champ Antonio Rodrigo Nogueira -- was scheduled to be the co-main event.
The UFC gave no indication of whether Griffin would be replaced or the fight would be scrapped altogether, but with more than three weeks until the fight date, it seems likely that a replacement could be found.
UFC 114 is main evented by the long-awaited grudge match between former light-heavyweight champions Rashad Evans and Quinton "Rampage" Jackson.