Since Kiyoshi Tamura is out of the tournament due to a broken hand suffered in the first round against Masakatsu Funaki, Melvin Manhoef, who won the reserve bout at DREAM 3, will enter the tournament. Manhoef's opponent will be Japanese superstar Kazushi Sakuraba.
Jason "Mayhem" Miller will take on grappling wizard Ronaldo "Jacare" Souza. Miller debuted for DREAM on May 10, stopping Katsuyori Shibata in the first round.
PRIDE veteran Gegard Mousasi will face off against Yoon Sik Dong.
And finally, Zelg Galesic, who put himself on the map with the UK's Cage Rage promotion, will fight Taiei Kin.
Previously announced was the second round lightweight bout between Shinya Aoki and Katsuhiko Nagata.
DREAM 4 will be televised live in the US on HDNet.