Gilbert Melendez's next title defense will be against Pat Healy.
Strikeforce announced on Wednesday that "El Nino," the promotion's lightweight champion, will meet Healy in the main event of its Sept. 29 event in Sacramento, Calf.
Heavyweight Daniel Cormier was scheduled to compete in his final Strikeforce fight in the co-main event, but he will now face Frank Mir later this fall.
The card, which will take place at the Power Balance Pavilion (formerly known as Arco Arena), will air on Showtime. The undercard will air on Showtime Extreme.
Melendez (21-2) has won his last seven fights in a row. He most recently defeated Josh Thomson via split decision in May.
Healy (28-16) enters the title fight riding a five-fight winning streak. He extended his streak earlier this month when he beat Mizuto Hirota via unanimous decision.
Tickets for the event go on sale to the general public this Saturday.