It looks like UFC 161 is going to need a new main event.
Tatame reported that Barao injured his right foot and would not have enough time to recover for the June 15 bout in Winnepeg, Manitoba, Canada.
Barao is believed to have one of the longest unbeaten streaks in MMA, having emerged from 31 straight fights without a loss. He is 30-1 with 1 no contest in his career.
Barao had been coming off one of his most impressive victories in the UFC, a fourth-round submission over Michael McDonald at UFC on FUEL 7 in February. Barao had hoped to beat Wineland and look towards a unification fight with injured champion Dominick Cruz.
With Barao out and less than a month to go until the show, the UFC is likely to promote one of two light-heavyweight bouts into the main card slot. In one, Mauricio Rua will face Antonio Rogerio Nogueira. In the other, Rashad Evans squares off with Dan Henderson.