Melendez, who is on a five-fight win streak, will look to defend his Strikeforce lightweight title for the third time. Masvidal is 2-0 this year and defeated K.J. Noons via unanimous decision in June to earn this title shot.
Cyborg, who is making her return after having her Strikeforce contract renewed in August, last fought back in June 2010. She'll defend her 145-pound belt against Yamanaka, a fighter who's made her name through the Smackgirl and JEWELS promotions in Japan.
The current fight card is below.
Gilbert Melendez vs. Jorge Masvidal
Cris "Cyborg" Santos vs. Hiroko Yamanaka
Gegard Mousasi vs. Ovince St. Preux
Billy Evangelista vs. K.J. Noons
Caros Fodor vs. Justin Wilcox
Devin Cole vs. Gabriel Salinas-Jones
Roger Bowling vs. Jerron Peoples