Cruz, who made his UFC debut in July over Urijah Faber, is taking part in the UFC's first title fight on free TV since Quinton "Rampage" Jackson vs. Dan Henderson at UFC 75 in September 2007.
Check out the rest of the UFC Live fight card below.
Versus Bouts - 9 p.m. ET
Dominick Cruz vs. Demetrious Johnson
Pat Barry vs. Stefan Struve
Anthony Johnson vs. Charlie Brenneman
Matt Wiman vs. Mac Danzig
Yves Edwards vs. Rafaello Oliveira
Michael Johnson vs. Paul Sass
Mike Easton vs. Byron Bloodworth
Shane Roller vs. T.J. Grant
Josh Neer vs. Keith Wisniewski
Walel Watson vs. Joseph Sandoval