Strikeforce confirmed the matchup will take place on June 18's Strikeforce: Overeem vs. Werdum event in Dallas.
Nunes made her U.S. debut on a January Strikeforce Challengers series card, knocking out fellow striker Julia Budd in just 14 seconds. The highlight-reel win opened many eyes and lifted Nunes' name into the conversation of 145-pound contenders.
Nunes started her career with a submission loss in March 2008, but has since rattled off six straight wins, all via knockout or TKO.
Kedzie will be no easy test for her. The 30-year-old is 16-8 in her career and is riding a four-fight win streak, with her most recent victory coming against Kaitlin Young on April 9.
Strikeforce: Overeem vs. Werdum takes place at the American Airlines Center in Dallas, and also boasts Heavyweight Grand Prix fights with Josh Barnett facing Brett Rogers and Alistair Overeem taking on Fabricio Werdum in the main event.