UFC president Dana White confirmed to MMA Fighting that both fighters are out.
According to sources with knowledge of the situation, Edgar had the more serious injury of the two, suffering two broken ribs during training, while Maynard suffered a knee injury.
The bout would have been the last of the trilogy. Maynard won the first bout in April 2008 in a unanimous decision. In January, the rematch ended in an all-time classic, with Maynard nearly knocking out the champion in the first round before Edgar rebounded with a gutsy performance to force a five-round draw.
Maynard-Edgar III is likely to happen in the future, but there is no timetable yet for its scheduling. With the recovery time of both men expected to be in the 6-to-8 week range, White suggested that it could be slotted into an August or September show.
With no replacement fight, Quinton Jackson vs. Matt Hamill will be promoted to the main event, while Frank Mir vs. Roy Nelson is the co-main event. A welterweight fight pitting Thiago Alves vs. Rick Story has been moved into the main card from the prelims.
UFC 130 takes place on May 28 from the MGM Grand Garden Arena in Las Vegas.