Overeem, the current Strikeforce heavyweight champion, will look to avenge a 2006 submission loss to Werdum at PRIDE Total Elimination Absolute in Japan.
The current fight card is below.
Showtime Bouts - 10 p.m. ET
Alistair Overeem vs. Fabricio Werdum
Josh Barnett vs. Brett Rogers
Daniel Cormier vs. Jeff Monson
Chad Griggs vs. Valentijn Overeem
K.J. Noons vs. Jorge Masvidal
Preliminary Bouts - HDNet 8p.m. ET
Gesias Cavalcante vs. Justin Wilcox
Conor Heun vs. Magno Almeida
Nah-Shon Burrell vs. Joe Ray
Todd Moore vs. Mike Bronzoulis
Brian Melancon vs. Isaac Vallie-Flag
Strikeforce: Overeem vs. Werdum airs live on Saturday, June 18 on Showtime at 10 p.m. ET from the American Airlines Arena.
Gina Carano was removed from the card after failing to receive medical clearance.