Matyushenko (24-5) is looking to rebound from his recent first-round TKO loss at the hands of Jon Jones in August. It was his first loss in the octagon in his second go-around with the company, previously defeating Jason Lambert and Igor Pokrajac.
Tatame.com first reported the opponent switch.
The 31-year-old Ferreira has been a submission machine throughout his long career, which dates back over a decade.
The Brazilian boasts an 18-6 record with 17 victories coming by way of submission.
Dating back to October 2005, Ferreira has captured 10 of his 11 bouts, finishing all his wins by first-round tapout.
UFC 122 takes place on Nov. 13 from Oberhausen, Germany.