Lesnar (5-1) puts his UFC heavyweight belt on the line for his third time in a matchup against undefeated Velasquez (8-0).
The stacked card also features the UFC debut of Jake Shields as well as appearances by Diego Sanchez and Tito Ortiz.
The complete pay-per-view card is below.
Pay-Per-View Bouts (10 p.m. ET)
Brock Lesnar vs. Cain Velasquez
Jake Shields vs. Martin Kampmann
Diego Sanchez vs. Paulo Thiago
Tito Ortiz vs. Matt Hamill
Brendan Schaub vs. Gabriel Gonzaga
Spike TV Bouts (9 p.m. ET)
Court McGee vs. Ryan Jensen
Patrick Cote vs. Tom Lawlor
Sam Stout vs. Paul Taylor
Mike Guymon vs. Daniel Roberts
Chris Camozzi vs. Dongi Yang
Jon Madsen vs. Gilbert Yvel