The event at the Jobing.com Arena will mark the first time the WEC -- and Zuffa -- has promoted a card in Arizona, a location determined by fans through AMP Energy's "Hometown Takedown Contest".
Henderson (12-1) signed the fight last week to make official the lightweight title defense in front of his hometown fans. He's 5-0 in the WEC and has been victorious in his last 11 fights. In April, Henderson submitted Donald Cerrone with a guillotine choke to retain the belt on WEC 's first pay-per-view at WEC 48. His opponent Pettis (12-1), a 23-year-old out of Duke Roufus' gym in Milwaukee, Wisc., is coming off three straight wins over Danny Castillo, Alex Karalexis and Shane Roller all in 2010.
The run-and-gun Cruz (16-1) broke out earlier this year by capturing the WEC bantamweight title away from Brian Bowles by TKO and in August retained the belt against Joseph Benavidez in a split decision. At the same August event at WEC 50, Jorgensen (11-3) defeated Brad Pickett to claim the No. 1 contender spot. A fighter out of his own Twisted Genetiks team, Jorgensen has won all five of his fights since October 2009.
WEC 53 will air on Versus at 9 p.m. ET.