Strikeforce announced the fights during Saturday's "Lawler vs. Shields" broadcast on Showtime.
Fans have been asking for Carano to meet Cyborg (7-1) since the two began to make their mark in women's MMA through the EliteXC promotion. Cyborg has won her last seven fights and her last was over the much smaller Hitomi Akano. Carano's fight was a unanimous decision over Kelly Kobal at EliteXC "Heat" last October on CBS.
Josh Thomson (16-2) won the Strikeforce lightweight championship over Gilbert Melendez (14-2) but has yet to defend it due to injuries. They were scheduled to meet in April, but Thomson suffered a broken leg. Melendez won the interim title at the event and he'll receive his chance to unify the titles in August.
Alistair Overeem, who has been away fighting for DREAM and K-1 in Japan, will return to Strikeforce at this event to defend his Strikeforce heavyweight belt.