Sanchez (22-2) made a smooth transition to lightweight at UFC 95 on Feb. 21 when he showed no signs of being affected by the tremendous weight cut by defeating Joe Stevenson via unanimous decision.
"Clay likes to push the pace and test a fighter's conditioning, but so do I," Sanchez said. "Right now, I'm at the perfect weight and it's the perfect time in my career to make a run at the title. I've already won a couple matches at the finales, so I'm feeling confident heading into this fight."
Guida (25-9) is aiming for a third straight win against a "The Ultimate Fighter" winner. Guida has won his last three, two of which were against season five and six winner Nate Diaz and Mac Danzig, respectively.
"I couldn't feel more confident about this fight right now in my career," Guida said. "We're both coming off three consecutive wins and we're two of the most explosive lightweights in the division. This has the potential to be fight of the year. My hands are going to be the best they've been... Vegas is where I do my best work."
Tickets prices ranging from $154 to $354 will go on sale Saturday, April 4 at noon PT.